Gout - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
Gout Remedy Natural Gout Treatment Treat Gouts Naturally Gout Prevention
 

New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.


Save 40% Off The Retail Price

People Said About Goutezol Gout Cure
"I was only 30 when I got a gout attack. Goutezol really helped me to get over the attack in just two days and the ebook helps me with watching what I'm eating. My uncle have had gout problems too, so I recommended your product. Thanks a lot!" Matt, California
gout treatment


 HOW PEGLOTICASE WORKS

What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS

Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It has been having a decent degree of success.

Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

 
60-Day Risk FREE Trial

People Said About Goutezol Gout Remedy
"week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago
gout treatment


In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

SIDE EFFECTS

Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.
Myrtle Randolph

 
 
     
 
 





Learn More about Natural Gout Remedy

Gout is a common disease and often presents suddenly with a painful joint. The most common and well-recognized symptom is swelling of the joint in the big toe where it joins the foot. This can be extremely painful and enlarged and if not treated the pain will last about 10 days and can cause lasting damage with repeated attacks. The area can be red, hot, inflamed and very painful or tender....


Our society is such that on a daily basis we unknowingly introduce our bodies to countless foreign substances. We are so conditioned to our way of life that we are not conscious to the fact that almost everything we eat, drink, breathe and put in or on our bodies is full of any number of food dyes, additives and preservatives. We routinely ingest toxic and often deadly chemicals such as chlorine...


Millions of people suffer from an agonizing attack on their body! Gout! Maybe you are currently dealing with gout symptoms? Possibly you are attempting to help a loved one who is suffering from late-night gout attacks. You have come to the right place! Knowledge of gout is the key to not only treating gout attacks and the disease, but also preventing additional damage to your body. Did you...


Remember when you could sleep the whole night without a flare-up of gout? Do you remember what it was like to not have to wince with pain when you walk? Fortunately, gout is treatable and curable and these 6 suggestions will get you on the right path to treat your gout symptoms. How Gout Works Gout is characterized with excruciating pain in the joint at the base of...


Gout is a fairly old disease, being around for more than two thousand years. Gout is a disease that affects mostly mean, but women can suffer from gout as well, mostly after menopause. Gout is a very hard rheumatic disease, but out off all this type of diseases, gout probably has the best treatment. There was a myth that said that the cause of gout is too much food and drinks. Nowadays,...


diet kidney stones | foods with uric acid | medication for gout | calcium kidney stones | what are purines adenine | prescribed for gout | signs and symptoms of gout | lower uric acid naturally | sudo gout | purin channel | kidney stone analysis | colchicine dosage doses side effects | dietary requirements for arthritis gout |







 
 
 
 
 
 
 
(c) 2019 goutdietscure.com
Contact Us | About Us | Privacy Policy | RSS Feed | Gout