gout home remedies joints - New Gout Drugs ??? Pegloticase Continues Its Hopeful Path
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New Gout Drugs ??? Pegloticase Continues Its Hopeful Path

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.


People with high uric acid can develop lumps under the skin and they are often found in or near joints previously attacked by gout and also on the elbow, over the fingers and toes, and in the outer edge of the ear, additionally, its increasing degenerative changes may make aging joints vulnerable, with cartilage fragments acting as seeds for crystal formation. Experts say the concentration in the blood is so high that the uric acid settles in the joints of people with gout, a leading cause of gout attacks.


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 SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

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Here are a few sources to consider. For tart cherries, Sunset Farms offers good pricing and good available. For "gout cherry juice", consider Traverse Bay Farms http://www.traversebayfarms.com . The company offers cherry juice, dried tart cherries and more. For tart cherry capsules, Fruit Advantage http://www.fruitadvantage.com offers free shipping on all super fruit tart cherry capsules.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

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For years, the story of the healing benefits of the tart cherry has been the source of legend and folklore for its natural healing benefits. In addition, to the tart cherry itself, more people are swearing by the juice produced from the tart cherry to have even greater benefits natural healing benefits than the fresh tart cherry. The juice produced from the tart cherry is call by many different names including "gout cherry juice", "tart cherry juice" and "tart cherry juice concentrate".

And it won't cost $1,000+! In fact, the cost could be as low as $20 for the store-boughten ingredients that neutralize the uric acid causing the pain.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

One of the most interesting study conducted on the tart cherry has revealed that the compounds in the tart cherry are a natural COX-1 and COX-2 inhibitors. This information is very encouraging, since these are the compounds that help to fight joint pain due to gout and arthritis. In addition, research results published in the British Journal of Medicine indicated that a tart cherry juice drink helped to reduce muscle pain due to physical exercise.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

I am writing this feeling appalled! One of my ex-gout customers wrote a recent e-mail to me stating the cost of gout medication. I was completely unaware of the extreme expense of gout medication. I guess, I just assumed that mediation couldn't be more than a few hundred dollars. However, I was wrong!

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Do you suffer from the arthritic pain of gout? Have you been taking medication with little to no relief? Are you tired of popping pills to hide the pain?

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

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Gout is the cause of uric acid in the body which is a by-product of a very necessary part of your body's normal function. In the case of gout, the body is unable to break down the high levels of the uric acid. The uric acid eventually develops into crystals which take up residency in your joints. The most typical joint affected is the toe. However, other gout joints affected include: the feet, the ankles, the wrists, fingers and elbows. If you or a loved one suffers from gout, you can neutralize the uric acid and eliminate the pain in hours.

 
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HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Gout Home-Remedy Neutralizes Uric Acid 1. Water could be one of the best remedies for every ailment. You should start making a habit of drinking 10-12 glasses of water per day. By drinking more water, you will urinate more thus flushing some of the uric acid build up. Water is great prevention.

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2. Vitamin C! Vitamin C has been documented to lower uric acid levels in the body as well as help the body's immunity. Do not exceed 2,000 mg of Vitamin C per day.

4. Begin eating healthier with fruits, veggies, fresh foods, whole grains and low fat foods. 5. Take a hike! Literally, go for a walk or a hike to get some exercise. After the area loosens up, your body will thank you and you will naturally lower the uric acid levels in your blood.

Gout is caused when a patient continuously has trouble digesting properly and waste matter from digested foods accumulates within the body, the excess uric acid then starts to crystallize and settle in the joints (especially on the feet), setting off inflammation, pain, and stiffness. Usually, the joints in the big toe are affected, but gout can also affect the instep, ankles, heels, knees, wrists, fingers and elbows.

3. Apple cider vinegar can help treat gout by being consumed or applied to swollen area. As a drink, you can actually add the vinegar to a cup of tea to change the pH of your blood which lowers the uric acid levels.

Medical Universities have conducted and published numerous studies on the healing benefits of the tart cherry and "gout cherry juice". While many studies exist and more studies beginning almost every day on the tart cherry, one underlying thread is present. The common underpinning of the studies is how the tart cherry and "gout cherry juice" is a natural anti inflammatory. In fact, according to research, no other fruit has been found to have the natural anti inflammatory properties of the tart cherry and "cherry juice concentrate".

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

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Gout is a form of rheumatic disease caused by uric acid deposits in the joints and it is marked by sudden attacks of painful, inflamed joints. It is caused by too much uric acid in the blood. It is the commonest inflammatory arthritis of men above 40 years old, and it is 20 times commoner in men than women; however, the number of postmenopausal women who have gout is increasing.

Gout is a complex disorder that can affect anyone. It is one of the oldest and probably most painful diseases known to mankind, which the symptoms develop at a quick pace. Fortunately, gout is treatable, and there are ways to keep gout from recurring.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

So what takes the tart cherry and "gout cherry juice" so legendary in fighting joint pain? Although food scientists are not absolutely certain on the specific compound that is 100 of the nutritional value of the tart cherry.

The connection between drinking alcoholic beverages and attacks of gout is a strong one for many with the disease; experts recognize that the standard goal in the treatment of chronic gout is the reduction and maintenance of sUA levels of less than 6 mg/dL.

Eating lots of cherries and fresh cherry juice has been highly recommended in the treatment of gout and gouty arthritis, another treatment that can be included simultaneously with herbal remedies for gout is the addition of rosehip tea to the diet, joints affected by gout will recover completely once the gout has been treated. For more info about Gout?, feel free to visit us at: http://www.about-goat.info


Myrtle Randolph

 
 
     
 
 





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