uric acid in women - Gout - Causes, Symptoms and Home Remedies
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Gout - Causes, Symptoms and Home Remedies

The word gout may make you think of kings and medieval history. But gout isn't a disease of the past. It's very much with us today. That's because gout is an inflammatory joint disease and a form of arthritis, not some mysterious illness of the rich and powerful.


31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.


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 uric acid in womenwithin a few hours the pain of gout will start to subside. Take ?? teaspoon of baking soda with meals. This will prevent gout attack Take Alfalfa daily. It is a good source of minerals and other nutrients and reduces serum uric acid

There are many natural remedies for Gout, but the most effective may be prevention. Prevention of Gout is only a few lifestyle changes and can significantly reduce the amount of time and irritation that result from the infliction of Gout.

Steve Warshaw - Certified Personal Trainer and Nutritionist With over 15 years expereience developing training and nutrition programs for top level executives from companies such as Microsoft, Boeing, and Symetra Corp, Steve has established himself as a health and wellness expert.

Normal results

Blood test

Reference values for blood uric acid vary from laboratory to laboratory but are generally found within the following range: Male: 2.1-8.5 mg/dL; female: 2.0-6.6 mg/dL. Values may be slightly higher in the elderly.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Uric acid is a waste product that results from the breakdown of purine, a nucleic acid. (Nucleic acids are the building blocks of DNA.) Uric acid is made in the liver and excreted by the kidneys. If the liver produces too much uric acid or the kidneys excrete too little, the patient will have too much uric acid in the blood. This condition is called hyperuricemia. Supersaturated uric acid in the urine (uricosuria) can crystallize to form kidney stones that may block the tubes that lead from the kidneys to the bladder (the ureters).

Regularly drinking alcohol interferes with the removal of uric acid from the body and can increase the risk for developing gout Extract the juice of half lemon and pour it in 1 glass of water. Drink it three times in a day.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

Description

The uric acid blood test is performed on a sample of the patient's blood, withdrawn from a vein into a vacuum tube. The procedure, which is called a venipuncture, takes about five minutes. The urine test requires the patient to collect all urine voided over a 24-hour period, with the exception of the very first specimen. The patient keeps the specimen container on ice or in the refrigerator during the collection period.

????? Deposits of uric acid crystals around joints and other areas such as the ears. ????? Only one or two joints are affected (initially). ????? Common affected areas include the feet, ankles and the ball of the big toe.

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To prevent future attacks, your doctor can prescribe a medicine to reduce uric acid buildup in your blood. Changing the way you eat can help you conduct your gout. Eat a healthy mix of foods so you get the nutrients you need. Limit foods like meat, fish, and beer. Drink plenty of water and other fluids.Life style changes such as limiting alcohol consumption, and limiting meals with meats and fish rich in purines can also be helpful in controlling gout. Weight loss may be very important this condition. You should also avoid certain animal proteins, such as: seafood; liver; kidney; heart; gizzard; sweetbreads; meat extracts; and gravy.

Urine test

Patients should be checked for the following medications before the urine test: diuretics, aspirin, pyrazinamide (Tebrazid), phenylbutazone, probenecid (Benemid), and allopurinol (Lopurin). If the patient needs to continue taking these medications, the laboratory should be notified.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

Decreased excretion of uric acid is seen in chronic kidney disease, low thyroid, toxemia of pregnancy, and alcoholism. Patients with gout excrete less than half the uric acid in their blood as other persons. Only 10-15% of the total cases of hyperuricemia, however, are caused by gout.

It occurs more frequently in countries that have a high standard of living. The most common sign of gout is a nighttime attack of swelling, tenderness, redness, and sharp pain in your big toe. There may also be the feeling that the skin around the area is stretching or tearing. There seem to be a number of factors that can cause people to develop gout. Some medications can prevent uric acid from leaving the body. Cyclosporine which is a medication used to suppress the body's immune system and prevent rejection after organ transplant, also increases the risk for developing gout. This can cause a build up of uric acid crystals.

Precautions

Blood test

Patients scheduled for a blood test for uric acid should be checked for the following medications: loop diuretics (Diamox, Bumex, Edecrin, or Lasix); ethambutol (Myambutol); vincristine (Oncovin); pyrazinamide (Tebrazid); thiazide diuretics (Naturetin, Hydrex, Diuril, Esidrix, HydroDiuril, Aquatensen, Renese, Diurese); aspirin (low doses); acetaminophen (Tylenol); ascorbic acid (vitamin C preparations); levodopa (Larodopa); or phenacetin. These drugs can affect test results.

Abnormal results

The critical value for the blood test is a level of uric acid higher than 12 milligrams per deciliter (about 3.4 ounces).

Urine test

Reference values for 24-hour urinary uric acid vary from laboratory to laboratory but are generally found within the following range: 250-750 mg/24 hours.

The laboratory should also be notified if the patient has had recent x-ray tests requiring contrast dyes. These chemicals increase uric acid levels in urine and decrease them in blood.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

The juice of French or string beans has also proved effective in the treatment of gout. About 150 ml. of this juice should be taken by the patient suffering from this disease. Raw potato juice and fresh pineapple juices are also beneficial.

Gout is one of the most common forms of arthritis (joint inflammation). Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout usually affects the first metatarsal phalangeal joint of the big toe (hallux) or the ankle joints. Gout most often affects the big toe but can also affect the ankle, knee, foot, hand, wrist and elbow. Approximately one million people in the United States suffer from attacks of gout. Gout is nine times more common in men than in women. It predominantly attacks males after puberty, with a peak age of 75. In women, gout attacks usually occur after menopause.

Herbal remedies for gout have become very popular in recent years. There is very little evidence right now that shows alternative therapies are effective for gout. Uricinex is a breakthrough herbal product that we have recently discovered. Blueberries are high in anti-inflammatory compounds called anthocyanins, which help ease the pain of gout. Other herbal treatments that have shown some success include vitamin C - Taking supplemental amounts of vitamin C helps some people to reduce the uric acid in their blood. Taking 2-3 teaspoons of black cherry juice a day helps some people. Cherries are a popular home remedy for gout.

Packing the effected joint in ice will help ease gout pain temporarily. Wrap an ice pack in a towel. (If you don't have an ice pack, put crushed ice into a plastic bag and wrap it in a towel.) Wrap the ice pack around the joint, and leave it in place for about twenty minutes. Repeat this treatment up to three times a day as needed.

 
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It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Apple Cider Vinegar is a wonderful old-timers home remedy, cures more ailments than any other folk remedy. Try 2 tbsp of organic apple cider vinegar mixed with 2 tablespoons of organic honey (2 times daily).

Certain foods that are high in purine may increase the patient's levels of uric acid. These include kidneys, liver, sweetbreads, sardines, anchovies, and meat extracts.

Definition

Uric acid tests are tests that are done to measure the levels of uric acid in blood serum or in urine.

Purpose



In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

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This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

Symptoms ????? Sustained high levels of uric acid in the blood is a common gout symptom (see causes of gout). ????? Presence of uric acid crystals in joint fluid (see diagnosis of gout).

Abnormally low uric acid levels may indicate that the patient is taking allopurinol or probenecid for treatment of gout; may be pregnant; or suffers from Wilson's disease or Fanconi's syndrome.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

Key Terms

Fanconi's syndrome
A rare disorder caused by vitamin D deficiency or exposure to heavy metals.
Gout
A metabolic disorder characterized by sudden recurring attacks of arthritis caused by deposits of crystals that build up in the joints due to abnormally high uric acid blood levels. In gout, uric acid may be overproduced, underexcreted, or both.
Hyperuricemia
Excessively high levels of uric acid in the blood, often producing gout.
Purine
A white crystalline substance that is one of the building blocks of DNA. Uric acid is produced when purine is broken down in the body.
Uric acid
A compound resulting from the body's breakdown of purine. It is normally present in human urine only in small amounts.
Uricosuria
Increased levels of uric acid in the urine.
Wilson's disease
A rare hereditary disease marked by the buildup of copper in the liver and brain, causing loss of kidney function.

Further Reading

For Your Information

    Books

  • Laboratory Test Handbook, edited by David S. Jacobs. Cleveland, OH: Lexi-Comp Inc., 1996.
  • Mosby's Diagnostic and Laboratory Test Reference, edited by Kathleen Deska Pagana and Timothy James Pagana. St. Louis: Mosby-Year Book, Inc., 1998.
  • Springhouse Corporation. Handbook of Diagnostic Tests, edited by Matthew Cahill. Springhouse, PA: Springhouse Corporation, 1995.

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In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

Increased production of uric acid may result from eating foods that are high in purine. Increased uric acid levels due to overproduction may also be caused by gout, by a genetic disorder of purine metabolism, or by metastatic cancer, destruction of red blood cells, leukemia, or cancer chemotherapy.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.



The uric acid tests are used to evaluate the blood levels of uric acid for gout and to assess uric acid levels in the urine for kidney stone formation. The urine test is used most often to monitor patients already diagnosed with kidney stones, but it can also be used to detect disorders that affect the body's production of uric acid and to help measure the level of kidney functioning.

Risks

Risks for the blood test are minimal, but may include slight bleeding from the puncture site, a small bruise or swelling in the area, or fainting or feeling lightheaded.

Preparation

The uric acid test requires either a blood or urine sample. For the blood sample, the patient should be fasting (nothing to eat or drink) for at least eight hours before the test. The urine test for uric acid requires a 24-hour urine collection. The urine test does not require the patient to fast or cut down on fluids. Some laboratories encourage patients to drink plenty of fluids during the collection period.

Causes Gout is caused by the buildup of uric acid in the joints. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases, approximately 18% of people who develop gout have a family history of the condition. Diseases and conditions that increase the risk include diabetes, obesity, kidney disease, and sickle cell anemia.

Alcohol and certain foods can trigger a gout attack. Events such as strokes, heart attacks or surgery may also cause gout. Gout is strongly associated with obesity, hypertension, hyperlipidemia and diabetes. Because of genetic factors, gout tends to run in some families. A variety of treatments can help you manage your gout. Traditionally treatment for acute gout has consisted of colchicine , which can be effective if given early in the attack. Gout often is treated with nonsteroidal anti-inflammatories (NSAIDs) such as naproxen (e.g., Anaprox, Naprosyn) and indomethacin (e.g., Indocin), usually for 3-7 days.

If you wish to learn more about Gout, Purines, or Uric Acid, check out Steve's s The Internet Guides. The Internet Guide: Uric Acid: http://gout.smartadssecrets.com/uric_acid

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.


Myrtle Randolph

 
 
     
 
 





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