allopurinol side effects - A New Gout Drug. Febuxostat wins marketing approval in the European Union
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A New Gout Drug. Febuxostat wins marketing approval in the European Union

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.


During one 12-year study, it was concluded that the risk for developing Gout was significantly increased in participants that drank at least six servings of sweetened carbonated soft drinks per week (these were non-diet sodas).


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 allopurinol side effectsAnd it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

Given that gout attacks are inflammatory, as shown by the painful inflammation of the affected joints, any substance which acts as an anti-inflammatory may make the attack less painful and inflamed. Fish oils have well researched anti-inflammatory properties.

Only a few vitamins have been really researched as contributors to a natural gout remedy. One is vitamin C which a few studies have found lowers uric acid levels somewhat. I have written about vitamin C for gout in earlier articles. Make sure you buy a Vitamin C preparation that contains added flavonoids, the more the better, to make it work more effectively. And buy a time (sustained) release Vitamin C product, because Vitamin C is excreted quickly.

Look closer at our every day consumption of liquids and their up close and personal relationship with Gout. Prevention of Gout is not that difficult. What you need is proper knowledge to treat Gout.

We expect that approximately two-thirds of the Uric Acid to be removed from the body through the kidneys and urinary system. Gout occurs when the Uric Acid is not metabolized properly enough to send it into the urinary system, so the blood levels reach higher proportions. Once there, the crystals may find a cozy joint (usually at the site of a big toe) to gather and collect and proceed to wreak havoc by means of intense, sudden pain and off-the-charts inflammation.

Rheumatoid arthritis is an autoimmune reaction resulting in a chronic, inflammatory condition affecting the joints and the tissues around them. The joints them??selves become painful, swollen, unstable, and then greatly deformed. It varies in severity.

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

Tip: Counter the ill effects of dehydrating liquids you consume, by drinking more water or decaffeinated teas and low sugar juices. Water is the key to good health. It is the cheapest medicine known to man. And it can take a commanding role to successfully treat Gout.

Treatment Diet and Nutrition Avoid shellfish, sardines, kidneys, and beans, and increase your intake of water. Biochemic tissue salts include Nat. phos and Nat. sulf.

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

John Mepham has spent much time researching gout. His best tip for curing gout naturally? Get to your ideal weight whatever the sacrifices may be. Learn more about natural gout treatment and natural remedies for gout at www.gout-smashers-guide.com It's an e-book with a emphasis on natural gout treatment.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

Homeopathy Specific remedies include Arnica 6c, Bryonia 30c, Rhus tox. 6c, and Ruta grav. 6c, but treatment should always be constitutional. Osteopathy Treatment will be to address the maintenance of body mechanics.

Beer carries the most risk, not only contains alcohol, which can cause dehydration, but it contains Purine as well. As discussed earlier, the higher amounts of Purine roaming in the body, the more Uric Acid will answer the call. And it is the Uric Acid crystals that cause the excruciating pain associated with Gout!

Potassium citrate is reported to be helpful in natural gout treatment, and has been the subject of gout studies. It aids excretion of uric acid, by raising the pH of urine. (Higher body pH levels make uric acid more soluble and thus better excreted). Potassium citrate can also head off the danger of kidney stones, of the uric acid variety, forming. One estimate is that there is a 20% chance that kidney stones will form in gout patients who also have acidic urine.

You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

Treatment Diet and Nutrition It is sensible to increase your intake of wholefoods, vegetables, and fiber. Reduce intake of meat, refined carbohydrates, and saturated fats. A qualified nutritional therapist will check for food allergies or intolerance, such as dairy, wheat, corn, and so on, and will, perhaps, suggest daily supplementation with vitamins C (2g), E (400iu), and B complex, along with calcium pantothenate, selenium (100mg), and zinc (30mg).

Quercetin may inhibit xanthine oxidase, the enzyme required to convert purines into uric acid. This is the method used by the leading long term gout pharmaceutical, allopurinol. Quercetin has done this in test tube studies.

Other vitamins which have been reported from various sources to help in natural gout treatment are quercetin, folic acid, potassium citrate calcium, and fish oils.

Healing This therapy can be beneficial. Gout Gout is caused by the buildup of crystalized uric acid around the joints, causing severe pain, swelling, and redness around them. It affects mainly the big toe, knuckles, knees, and elbows. An attack may be accompanied by a high fever, and repeated attacks damage bones. Gout is usually an indication that the body is not processing and removing uric acid efficiently.

You can prevent Gout. Follow the steps and tips listed here. To avoid Gout or hasten the process of curing Gout avoid Purine rich foods and beverages such as organ meats, poultry, seafood and products containing yeast.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

Coffee Studies have been conducted that connect the drinking of coffee - and the more of it the better - with marked prevention of Gout in significant numbers of participants. Experts conclude that there is a correlation between elevated insulin levels and the presence of higher Uric Acid levels in the bloodstream. The researchers believe that drinking coffee lowers the level of insulin, and with it decreases the Uric Acid levels. Drink another cup of java and help yourself avoid Gout!

Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

 
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Rheumatoid arthritis is a systemic disease that begins with severe pain in the small joints of hands and feet, spreading to the wrists, knees, shoulders, ankles, and elbows. Overlying skin appears red and shiny. This condition affects mostly women, often beginning between the ages of 20 and 40, although it can occur at any time. Symptoms include joint pain, swelling, and stiffness, accompanied by fatigue, low-grade fever, and poor appetite.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

Elevated levels of Purine present in the body at any given time, whether due to genetics or a high protein diet, may give rise to elevated amounts of Uric Acid in the blood stream.

Learning what it takes to successfully cure or treat Gout is as important as knowing the root causes behind it. First you need to understand what causes Gout so that you can avoid Gout as well as treat Gout.

Alcohol News flash: Drinking alcohol increases the risk for Gout! There is a proven and direct association between alcohol consumption and the presence of Gout. Therefore, if you are an avid drinker, there's no way you can avoid Gout. The risk is greatest for beer drinkers followed by those indulging in liquor, but wine (in moderation) does not seem to have much of an effect on the incidence of Gout.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.

Calcium may be helpful because it helps to alkalize the body, (i.e. it raises its pH levels making the body more alkaline) and thus, the theory is, more uric acid will be excreted. In pH theory, because the blood's pH must be maintained at pH 7.365, the body will scavenge calcium from bones to maintain blood pH at 7.365. Most people, it's said, and probably most gout sufferers too, have acidic bodies (which ought to be alkaline) and therefore a deficiency of calcium.

Since our bodies rely heavily on the urinary system to rid us of excess Uric Acid, it is easy to understand why good hydration and fluid balance is so important. The balance of fluids in our systems plays an integral role in Gout prevention, cure and Gout treatment.

But it goes further. Sugary fruits and juices such as apples and oranges appear to carry an increased risk of Gout as well. For the person trying to avoid Gout flare-ups, the ill effects of sweetened soft drinks proved to be worse than hard liquor and almost as negative as beer. Fructose appears to be the culprit, having been found to raise Uric Acid levels.

Folic acid has been found in at least one study to be helpful because it inhibited xanthine oxidase, but in others to have no effect. It was part of the late Dr. Atkins's (the Atkins diet) formula for curing gout naturally but in large amounts. It should certainly only be taken under supervision by a qualified and experienced practitioner.

Sweetened Drinks Americans are drinking more sugary soft drinks than ever, but is there a coincidental rise in occurrence of Gout as well?

Vitamins work in other ways to help in natural gout treatment. Those that work as antioxidants perform the helpful function of squelching free radicals. Why is this helpful? Because during gout attacks, free radical levels rise. Some leading antioxidant vitamins are vitamin C, vitamin E, beta carotene and selenium.

In addition to preventing Gout's acute attacks, the effects of good hydration helps keep joints lubricated, flushes Uric Acid out of the body and away from the poor great toe and other inflicted joints and prevents or helps kidney stones pass through if present. The kidneys cannot function optimally in a dehydrated state, nor does any system in the body.

To treat and prevent Gout effectively, switch to water, low sugar juices or diet sodas and drink plenty of them.

Hydrotherapy Cold compresses are useful when the joints are acutely inflamed, followed by alternating hot and cold compresses. Massage Joints can be massaged with tiger balm, lavender, and camomile oils, and Ruta graveolens cream.

Ensure the fish oil supplement you buy has been manufactured with a molecular distillation process. It takes out mercury, PCBs and dioxins. Since cherries have been researched as blocking inflammation, they should be considered. Cherries have also been found in studies to lower uric acid levels. When they are not in season their dietary supplement extracts, juice and in dried form can be taken. Cherries enjoy testimonials from gout sufferers both for curing gout naturally and halting the pain of attacks, but they won't do this for everyone. Celery, in two studies, also reduced pain and inflammation, so you can consider celery seed extract as part of natural gout treatment.

Chiropractic and Osteopathy Both provide foot mobilization maneuvers to help the condition.

It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

John Mepham has lost track of the number of hours he has spent researching gout treatments. His best tip for curing gout naturally? Get to your ideal weight whatever the sacrifices may be. Learn more about natural gout treatment at www.gout-smashers-guide.com It's an e-book with an emphasis on natural gout treatment

Massage Oils of peppermint, lavender, camomile and geranium may be massaged into the affected area. Ruta graveolens cream may also be used. Self-mobilize the toe by gently pulling it and moving it around.

Fish oils are also good for gout because they promote a healthier body. Their omega -3 fatty acids (EPA and DHA) are a dietary deficiency for many people, especially those who don't eat fish. Omega -3 fatty acids are required to bring about a better balance of omega -3 and omega -6 oils in the body. Most people, it is thought, do get sufficient omega -6 fatty acids, especially if they fry with oils such as corn, soy, sunflower, safflower or sesame. Or, if they use these oils as salad oils. But people don't get enough of the omega -3's. This better balance promotes better health. Gout sufferers need to be as healthy as possible. Note: gout sufferers should not eat fish high in purines such as mackerel, anchovies, and sardines.

Acupressure Massage of points relating to the feet will be useful. Consult a qualified practitioner/therapist for: Herbal Medicine Celery seeds, and wintergreen teas; bladderwrack may be taken internally, or seaweed can be eaten or added to the bath. Burdock and nettle neutralize and eliminate poisons from the body. A poultice of comfrey and marigold may be useful.

Read on... Water The most abundant home remedy to prevent Gout on the planet is at our fingertips. Water! There is no cheaper alternative to treat Gout. An individual seeking to prevent Gout or curing Gout it would be wise to drink as much as 96 ounces of water per day to maintain hydration and dilution of Uric Acid crystals in the bloodstream.

The cycle of Gout begins with the presence of a substance called Purine, which is formed during the normal decomposition of protein molecules in our cells. A by-product of Purine is a crystalline substance called Uric Acid.

At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.

Consult a qualified practitioner/therapist for: Acupuncture This will be aimed at energy balance, and pain relief. Herbal Medicine Useful herbs include black cohosh, wild yam, willow bark, and licorice.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

Got beer? In order to prevent Gout, treat Gout or cure Gout, you already know the answer!

Betty Roberts is the author of Gout-Info.com, a website dedicated to Gout sufferers.


Myrtle Randolph

 
 
     
 
 





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