gout drug - A Diet Plan for Gout With a Cherry On Top
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A Diet Plan for Gout With a Cherry On Top

Almost 90% of gout victims are men over thirty years old. But women can also suffer from gout, especially if they take certain medications such as blood pressure drugs. Most women who suffer from gout are 60 years or older.


In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.


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 Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.

- corticosteroids are the alternative for a gout patient who can not use the nonsteroidal drugs; these as well reduce the inflammation caused by the gout in no more than a few hours; you can find this type of gout drug in form of pills or injections;

Gout treatment should be started as soon as possible. An acute gout case can be treated with nonsteroidal drugs that also prevent inflammation, such as ibuprofen or indomethacin. If you suffer from a kidney problem or a peptic ulcer besides gout, then these drugs can not be used because they can make the other conditions worse. Another drug that can be used in gout is colchicine. However, this medication causes diarrhea, that only goes away after you stop using the drug. Corticosteroids can also be given to treat a gout case. They can be given orally or injected directly in your joint. The main thing that you have to remember is that aspirin or drugs that are closely related to it should be avoided in gout cases, because they can only make the condition worse.

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

There are many reason that can cause a gout. The main risk factor in a gout case is the levels of uric acid that one has in his/ her body. This increased levels can be cause by many factors, and diet is one of those.

WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

It occurs more frequently in countries that have a high standard of living. Mostly male over the age of 40. Gout affects up to 500000 (1 to 30) of Canadians. Gout attacks usually the big toe (about 75 percent of initial attacks), but it can also affect other joints such as the ankle, heel, foot, knee, wrist, elbow, fingers, and the spine. The most common sign of gout is a nighttime attack of the swelling, tenderness, redness and pain in your big toe. Gout is strongly associated with obesity, hypertension, hyperlipidemia, and diabetes. Due to genetic factors, the drop tends to run in some families. Gout can be inherited or occur as a complication of another condition. The use of thiazide diuretics used to treat high blood pressure and low dose aspirin may also raise levels of uric acid.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

It's best to eat the cherries or drink the cherry juice between meals. So why do cherries work for some people with gout? Because gout destroys the collagen that is needed to form connective tissue and cherries stop that destruction. Cherries also neutralize uric acid and have anti-inflammatory properties.

6. Vitamin C, taken in high doses, can help decrease blood uric acid levels.


7 NSAIDS such as indomethacin (Indocin) and naproxen (Naprosyn) are effective anti-inflammatory medications for acute gout.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

To treat a chronic gout cause actually means to prevent the reoccurring of an acute gout case. This is mostly done by decreasing the levels of uric acid.

Important Disclaimer: This information is presented for educational purposes only. This isn't medical advice and it's not a substitute for any advice or treatment from your physician. You should always see your doctor before starting any new diet plan for losing weight or controlling gout.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

Pain medication is the main drug used in gout treatment. Because got patients suffer from excruciating pain, they have to alleviate this gout symptoms and the best way is to take pain medication. However, beside this a gout patients must rest a lot and drink a lot of fluids. Drinking alcohol and eating very much was thought to be the main cause of gout. Nowadays, doctors have proven otherwise. However, eating a lot and drinking big quantities of alcohol is highly related to gout attacks. This is the main reason why you should reduce the amount of alcohol that you drink and try to eat less to prevent gout attacks. Unfortunately, besides these two things, there is not much one can do to prevent a gout attack. There are also some medication that can help prevent a gout attack, but in may cases they do not work. Most gout attacks have a sudden onset and they have to be treated with medication.

To control and treat a gout takes more than medication. A diet and probably a change in your lifestyle must also be made if suffering from a gout. The medication that you will be prescribed to treat your gout case depend on some factors. Your doctor will give you the proper gout treatment after taking into consideration your age, state of health, other medication that you take and last but not least the severity of your gout attacks. The main drugs that you will be given are anti- inflammatory medicine:

Cherry juice or cherries is also good for preventing gout flares. So eat at least a half pound of these fruits to better manage your gout. It does not matter what kind of cherries you eat. All cherries are beneficial in gout cases. Cherry juice is also believed to be very good in relieving some of the gout symptoms, although this has not been proven yet. So as you can see, this tiny fruit can do a world of good in your gout case. There are also some other changes that you have to make if suffering from gout. Besides the dietary modification that you should do, some lifestyle changes must be done as well.

Gout treatment, like many other disease treatments, is aimed at relieving the symptoms and not at healing gout, because this is not possible. Gout treatment also tries to prevent long term damage of your joints. One you have gout there is nothing you can do to cure this medical condition, but with the proper treatment you can prevent other bad things from happening as a result of gout and you can also alleviate the pain that you have when suffering from gout.

 
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Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

If gout isn't properly controlled, it can cause kidney stones and even more serious kidney disease. Gout is also associated with high blood pressure, diabetes, and atherosclerosis.

Certain types of foods have in their composition purine. These compounds are known to rise the levels of uric acid. In turn, uric acid is what cause a gout. So, if you stop eating such foods, or at least try to reduce the number, then you can prevent gout attacks. Here is a list of foods that are high in purine, thus leading to gout: bouillon, brains, goose, sardines, dried vegetables, shrimp, heart, liver and many others. These are just some of the foods to avoid if suffering form a gout, or if you are one of those people susceptible to a gout. Furthermore, alcohol is also known to do a lot of damage in gout cases. Try to avoid as much as possible drinking alcohol, especially beer, if you want to lower the number of gout flares. If you can avoid the purine foods and alcohol, you will surely feel a difference in the number of gout flares, as well as in the gout signs. Levels of uric acid can also be risen by sugar and fructose. So if you want to control your gout case, then try to avoid them as well.

Gout Treatment and Prevention Tips 1. Drinking alcohol should be reduced or stopped. 2. Try to keep your weight down. 3. Use helpful devices such as a cart to carry your grocery bags.

You should always consult a doctor for treatment of gout. But some of the drugs used for gout - such as allopurinol, colchicine, indomethacin, and prednisone - can cause serious side effects.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

Gout is sometimes called the "disease of kings" because it has long been associated with the wrong kind of excess in food and wine, only the rich and powerful could afford. Gout is one of the most common forms of arthritis (inflammation). Gout is the state resulting from uric acid crystals in the filing of body tissues. Gout is characterized by an overload of uric acid in the body and recurring attacks of inflammation (arthritis). The chronic gout can lead to hard nodule deposits of uric acid in and around the joints, decreased renal function and kidney stones. Gout affects about 1 in 100 people and less than 6 to 7 per cent of older men. Men are more likely to find that women are the drop, but women are becoming more sensitive to the drop after menopause.

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

Losing excess weight may also reduce uric acid levels, but it must be done gradually and under a doctor's supervision. Severe dieting or fasting can actually make your gout worse.

If you are intersted in finding more information about gout you can click on this website http://www.gout-info-center.com. Also you will find there valuable information about gout symptoms and gout treatments.

4. Applying heat helps relax aching muscles, and reduces joint pain and soreness. 5. Applying cold helps to lessen the pain and swelling in a joint.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

- the most used gout drugs are anti- inflammatory drugs which have no steroids; ipubrofen is usually prescribed to a gout patient; this is a very used drug, because after taking it, the pain and inflammation that is caused by the gout flare will pass in a couple of hours;

So, as you can see, medication is not the only way to go if suffering from a gout. Some people even say that drugs are not so very useful in gout cases. Because gout is a condition that has long lasting effects, other "treatments " must be used besides medication.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

John Mepham has lost track of the number of hours he has spent researching gout treatments. His best tip for curing gout naturally? Get to your ideal weight whatever the sacrifices may be. Learn more about natural gout treatment at www.gout-smashers-guide.com It's an e-book with an emphasis on natural gout treatment

Many other people - some of whom have written to Prevention magazine - have also found relief by adding cherries to their diets. Supposedly, if you already have crippling gout or if you feel a gout attack coming on, you should eat 15 to 30 cherries a day at first to get your gout under control, then 6 to 10 cherries a day after that to keep the gout away.

A gout is a type of arthritis, which is the inflammation of your joints. In got cases, the attacks cause severe pain, sewlling and redness. These gout attack symptoms happen very sudden, without any further warning. To heal a gout case is impossible, because their exists no cure. However, there are things that can be done to control and treat your gout case.

There are other changes you can make to your diet, too. For example, eating a cup of strawberries may help to control gout. You should also drink plenty of water to help flush the uric acid out of your body. Six to eight 8-ounce glasses a day is probably best.

Gout is a form of arthritis caused by high levels of uric acid in the blood, tissues, and urine. The uric acid can form crystals which collect in joints such as the big toe. In fact, your big toe can become so painful and swollen that even the weight of a bedsheet can be agonizing.

Red and black cherries - fresh, frozen or canned - have been used successfully to treat gout. Drinking several tablespoons of black cherry juice daily may produce the same effect.

Some high-purine foods are meats, especially organ meats, gravies, herring, mussels, sardines, fish, and alcohol. At least one study suggests that high-purine foods such as beans, peas, mushrooms, spinach and cauliflower do not make gout worse. But you should consult your doctor for the latest information and recommendations.

He discovered his "cherry cure" by accident. One day, he ate a large bowl of cherries and the next day, his foot pain was gone. He found that as long as he ate the cherries every day, his gout was controlled.

- another drug used to calm down the gout flare symptoms is colchicine; its effect can been seen in a few hours time; Besides these drugs that are used to reduce the symptoms of a gout flare, there are also other drugs for preventing the gout attacks from happening. Allopurinol or probenecid lower the levels of uric acid that you have in your blood, thus reducing the risk of another gout attack. They are only given to the gout patients that suffer from many gout flares or have kidney stones because of the uric acid. However, if the levels of uric acid are lowered too sudden, this may trigger a gout attack as well. To prevent this from happening, doctors also prescribe colchicine to gout patients who take drugs to lower the levels of acid. Furthermore, the therapy with acid- lowering drugs is not started when the patient is suffering from a gout attack.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.


Myrtle Randolph

 
 
     
 
 





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