gout in knee symptom - Too Young For Gout Disease At 30? Think Again...
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Too Young For Gout Disease At 30? Think Again...

Gout disease is most common in people between the ages of 30 and 50 years of age. The reason for this is that it takes a build up of about twenty years to cause a first gout attack. Uric acid levels will usually begin to increase at least that far ahead of the onset of gout. However, this does not rule out gout in people younger than 30 years old. Therefore, just because you're under 30, it doesn't mean that you can't develop gout.


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" Tart cherry capsules are made with tart cherry powder. The tart cherry powder is made using the freeze-dried process. The freeze dried process uses low heat and low temperature, thus maintaining 100% of the phytochemicals of the tart cherry. A good source of tart cherry capsules is Fruit Advantage http://www.fruitadvantage.com

NB. The contents of this article contain medical information not medical advice. Please always discuss remedies with your doctor or other health care professional, before implementing any treatment.

Noted possible side effects dizziness, drowsiness, diarrhoea, rashes, headaches, hypertension and liver function abnormalities - considered mild ones. In trials none of these side effects were reported in more than 3.5% of trial patients. The most common were liver function abnormalities.

WHO WILL BE PRESCRIBED IT? The recommended dose is one 80 mg daily tablet. If after two weeks there is no reduction in UA levels, your doctor may increase the dose to 120 mg daily. Patients will need another serum UA test after two weeks treatment to find out how well it's doing. In trials it has usually worked quickly, within a couple of weeks.

It has been having a decent degree of success. Elimination of gout attacks In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.

If you don't want to take medication, due to possible and serious side effects, you have another alternative that can be better then medication - eating the right food.

Approval in one country does not mean approval in another, but the fact that the European Medicines Agency has approved it will carry weight when the medical authorities in other countries consider its approval.

Eating right and selecting low purine foods can help you to manage gout pain and enjoy a painful life.

31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial. It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.

Stage #1: Higher levels of uric acid begin to form. This first stage is called Asymptomatic Hyperuricemia. In this stage, you will probably not feel any symptoms. Catching the gout at this stage is vital so you don't experience the pain of the gout.

You probably already know gout is caused by high levels of uric acid in the blood. However, did you know that four stages of gout exist and each stage has very unique characteristics of this painful infliction?

NB. The contents of this article contain medical information not medical advice. Please always discuss gout remedies with your doctor or other health care professional, before implementing any treatment.

HOW PEGLOTICASE WORKS What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.

Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009.

In May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.

In the world of natural gout remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.

If you have severe kidney or liver problems Febuxostat is not recommended since it has not been tested in these patient groups. It is not recommended for people with heart disease or children.

SIDE EFFECTS Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients. The developing company has said that most were mild, moderate, or controllable. But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes.

It will also only be used in gout patients who have chronic hyperuricemia (high UA levels) and gout. So if you're a gout sufferer who lives in a European country that's a member of the EU, you can ask your doctor's opinion about whether Febuxostat is suitable for you.

Stage #3: This stage is Intercritical gout. This is when an gout attack has subsided. This is the stage the body begins to stabilize itself and fights the uric acid crystals in the joints. Getting treatment is vital at this stage if the individual wants to control the gout.

Reduce your alcohol consumption, especially if you tend to binge drink or drink to excess. Alcohol is not a cause of gout, but it can negate all of your other efforts to prevent gout disease from acting up. Alcohol will dehydrate your body and it causes uric acid to form. Therefore, it not only builds your uric acid levels, but it discourages your body from eliminating that uric acid. So it is best to avoid alcohol altogether when you are working to prevent gout disease.

Now that you know a few of the foods to avoid here are few suggestions on what foods to eat. Here a brief list of foods that are low in purines and you should incorporate them into your diet. These foods include peanut butter, oatmeal, eggs, cereals, fruits and milk.

" Cherry juice concentrate is a highly concentrate way to get the pain relieving property of the tart cherry. It takes approximately 100 cherries to make just one ounce of tart cherry juice. A reliable source for tart cherry juice concentrate is Traverse Bay Farms http://www.traversebayfarms.com

Even if you are already at a healthy body weight, you should examine your diet and make healthy dietary changes to include optimum nutritional choices, and low quantities of foods that are both high in purines and in proteins. These foods, such as meat, fish, and beer, are the primary causes of increased levels of uric acid in the body and should therefore be avoided.

By taking these basic healthy precautions, you will be able to minimize the impact gout has on your life, and delay its onset for several years.

Your next step is maintaining a healthy body weight. If you are overweight - especially if you are obese - it is important for you to speak to your doctor about losing weight gradually and in a healthy way so you achieve a healthy body mass and maintain it. Though being overweight doesn't directly cause gout, it can put you at higher risk of having attacks. However, take care not to lose weight too quickly as crash dieting can actually increase uric acid levels and lead to a gout attack.

Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.

 
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"week ago i couldnt walk and was in terible pain. i though my big toe was broken i would need a surgery, but doctor said it was gout. After taking some pain killer and goutezol for 2 days i can walk again. thank you" Peter from Chicago
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Here is a brief list of foods that are high in purines and should be avoided since high purine food contributes to the gout. These foods include alcohol, seafood, beans, scallops, and sweetbread.

BENEFITS In large trials Febuxostat (Adenuric) has outperformed Allopurinol, the most common gout medication for long term treatment. Like Allopurinol, it works to lower uric acid production by inhibiting xanthine oxidase, an enzyme required to produce uric acid. In two major studies it reduced uric acid (UA) in more gout sufferers, and more patients reached the target 6.0 mg/dL level more quickly, than did those on Allopurinol.

TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.

It has taken a very long time for a major new gout drug to be developed and approved. Probably the best gout news in over 40 years, is that Febuxostat, which has been given the trade/brand name of Adenuric, has been approved by the European Medicines Agency for marketing in European Union (EU) countries.

You will not need to be on a low purine diet, and more good news is that it can be prescribed for the elderly. Kidney and liver disease In trials it has performed quite well with patients who have mild kidney disease. 44% of patients achieved the target at an 80 mg dosage, more at higher dosages. Better results than Allopurinol. If you have mild kidney disease (renal impairment) or mild liver problems (hepatic impairment) your doctor will judge whether Adenuric/Febuxostat can be taken safely.

Generally, Febuxostat has been more effective when UA levels are below 10.0 mg/dL (595 mmol/??mol). However, even if they have been above this level, it has reduced UA levels down to the target in about 40% of study patients at an 80 mg dosage, and by more at higher dosages.

Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.

Tophi If you have tophi, it's heartening to know that Febuxostat has been shown to have success against tophi. Measured tophi areas reduced in many patients with tophi. The presence of tophi will be an additional factor in favour of a decision to prescribe Febuxostat (Adenuric).

For example one fruit that has a proven track record in fighting gout pain is the tart cherry. Tart cherries have been proven by medical research universities to help fight gout pain. The benefit of the tart cherry is this little fruit is available is a variety of options including tart cherry juice and tart cherry capsules. Here is a brief overview of the different ways to fight gout with tart cherries:

Stage #2: The gout starts to harm the body. This second stage is called acute gouty arthritis or acute gout. This is the stage that jagged crystal-like formations begin to deposit themselves in joint spaces. This is also the stage when redness, pain and swelling occurs.

This approval applies only to EU countries. Febuxostat has not yet been approved in the United States. If you are reading this from a non-EU country, or the US, you can check with your doctor to find out whether, or when, Febuxostat will be approved in your country.

Your uric acid levels will have to be high. If you have gout but normal or slightly raised uric acid levels as some do, it is unlikely to be prescribed.

Stage #4: This is the final stage of gout and it is called chronic gout. This stage can cause permanent damage to the joints and kidney, too. Eating Right Can Stop the Gout.

It is recommended that NSAIDs or Colchicine are used along with Adenuric. This is because, as with Allopurinol, on a course of Febuxostat, there may be an initial increase in gout flares. If this happens you must battle through the attacks and continue taking Adenuric.

In other patient groups there were reductions in attacks and improvement in tophi reduction. Tophi are those knobbly shaped, awkward looking, lumps of MSU crystals that often develop in longer term gout sufferers.

May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.

At 120 mg it has reduced UA levels to the target of 6.0 mg/dL in over 60% of study patients. At 80 mg the numbers were around 51%. Allopurinol at a 300 mg dosage in most participants achieved this is 22% of study patients. Hence the excited buzz in rheumatology circles since these kinds of results became apparent in its trials. At or below 6.0 mg/dL gout is more likely to be cured or managed better.

The first step is to make sure that you are always adequately hydrated. Of course, this is a good piece of advice for your health regardless of gout, but it is especially important when you are trying to prevent the condition. This is because hydration is the primary step for helping to flush uric acid from your body. The buildup of uric acid on the joints is the primary cause of gout and therefore the main goal of gout prevention is to stop that from happening.

If you have hyperuricemia, you are at a higher risk for gout disease. Hyperuricemia means that you already have high uric acid levels in your blood. If this is the case, your doctor may prescribe medications to help control that condition. By keeping hyperuricemia under control, you can also help to slow the onset of gout and prevent gout disease occurrences.

And it may cause side effects of course. See the bottom of this article. Febuxostat (Adenuric) is not unfortunately a treatment for gout pain. It won't be used instead of NSAIDS like Indomethacin, Colchicine, and corticosteroids.

This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension.

Although not common, gout disease can occur in those younger than 30 years old; usually as a result of an enzyme problem or kidney disease. However, when not a result of another problem in the body - for example, when gout is simply hereditary in your family - there are steps you can take to prevent the early onset of gout.

IT'S NOT PERFECT In trials its success rate in reducing UA levels down to the important 6.0 mg/dL (357 mmol/??mol) level was not 100%. About 35% of trial patients did not achieve the target. This may have been partly because so many gout sufferers are not UA over-producers, the problem Febuxostat addresses, but under-excretors of uric acid.

John Mepham has lost track of the number of hours he has spent researching gout treatments. His best tip for curing gout naturally? Get to your ideal weight whatever the sacrifices may be. Learn more about natural gout treatment at www.gout-smashers-guide.com It's an e-book with an emphasis on natural gout treatment


Myrtle Randolph

 
 
     
 
 





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